Profound fatigue has negative impacts on the day-to-day lives of patients with CAD1

In an interview-based study of patients with CAD who, on average, were diagnosed 6 years prior (N=16)*

Patient reported symtoms of CAD chart image

of patients reported CAD-related fatigue as one of their most bothersome and/or most important symptoms to treat

Patients with CAD face a significantly increased risk of medically attended depression and anxiety

Data from a retrospective study subanalysis of patients with CAD (n=384) vs matched comparisons (n=2789)


higher risk for medically attended anxiety or depression
aHR (95% CI): 1.6 (1.3-2.1)

higher risk for prescription medication or psychotherapy to treat anxiety or depression
aHR (95% CI): 1.8 (1.2-2.9)

Patients with CAD required extensive healthcare resources3

In a retrospective claims-database study of patients in Europe with CAD (n=85) vs matched comparisons(n=826)

Healthcare resource utilisation chart

Meet Brad

Hear from Brad, a patient with CAD, as he discusses his path to diagnosis, the impact CAD has on his daily life, and the challenges he’s faced because of his disease.

Meet Sharon

Hear from Sharon, a patient living with CAD whose road to diagnosis was unclear and confusing for her and her family.

Meet Fred

Hear from Fred, a patient living with CAD, about the struggles he’s faced due to his diagnosis.

Serious risk icon

CAD can have serious consequences

Haemolysis icon

In CAD, activated C1 drives chronic haemolysis

aHR=adjusted hazard ratio; CAD=Cold Agglutinin Disease; CI=confidence interval; ICD=International Classification of Diseases; OR=odds ratio.

*Previous CAD treatment was not systematically collected for all subjects and is a limitation of the study. 
Reactions to cold environments included cold or numb feet, hands or other body parts; skin discoloration; muscle aches or headaches; and fatigue. 
Sleep disturbances included problems falling asleep or staying asleep. 
§Medically attended anxiety or depression was defined using International Classification of Diseases (ICD-9 and ICD-10) codes for inpatient states and outpatient hospital visits, medication class, and procedure codes for psychotherapy. 
||Patients with CAD were matched (1:10) to non-CAD patients by age (±3 years), sex, race, region of residence, and active time and season and year of entry date in the Optum health plan. In this sensitivity analysis, patients with cold agglutinin syndrome secondary to coexisting malignancy or infection were excluded. Cox proportional hazard models adjusted for age, sex, race, region, comorbidity score and cluster.
Patients with CAD were matched without replacement 10:1 with comparison patients from the general population based on age (±3 years), sex and Charlson Comorbidity categories.
**After index date.

References: 1. Su J, Kosa K, DiBenedetti D. Patient-reported disease burden: In-depth interviews of patients with CAD. Blood. 2020;136(suppl 1):29-30. dol:10.1182/blood-2020-136788 2. Patel P, Jiang X, Nicholson G, et al. Medically attended anxiety or depression is increased among newly diagnosed patients with cold agglutinin disease (CAD). Blood. 2020;136(suppl 1):28. doi:10.1182/blood-2020-139791 3. Vágó EK, Nicholson G, Horváth-Puhó E, Hooda N, Fryzek JP, Su J. Healthcare resource utilization among patients with cold agglutinin disease in Denmark. Curr Med Res Opin. 2021;37(10):1829-1835. doi:10.1080/03007995.2021.1960494